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Impact of a Patient-Centered Program for Low Anterior Resection Syndrome: A Multicenter, Single-Blinded, Randomized Controlled Trial Richard Garfinkle, Marie Demian, Sarah Sabboobeh, Sahir Bhatnagar, Julie Savard, Sebastien Drolet, Sender A Liberman, Carl J Brown, Jason Park, Jeongyoon Moon, Carmen G Loiselle, Steven D Wexner, Liliana Bordeianou, Gabriela Ghitulescu, Julio Faria, Nancy Morin, Carol-Ann Vasilevsky, Marylise Boutros

2025 Sep 1;282(3):361-370. doi: 10.1097/SLA.0000000000006777. Epub 2025 Jun 12.

The use of patient-generated health data in the management of low anterior resection syndrome: a qualitative study. Monton O, Smith A, Sabboobeh S, Demian M, Cornish J, Wexner SD, Christensen P, Ghuman A, Bordeianou LG, Keane C, Husain S, Gasior A, Leon N, Savard J, Savitt LR, Majgaard M, Sørensen GK, Mills M, Rajabiyazdi F, Boutros M. T

Frontiers in Surgery. 2024 Dec 19;11:1506688. DOI: 10.3389/fsurg.2024.1506688

An online educational and supportive care application for rectal cancer survivors with low anterior resection syndrome: A mixed methods pilot study Monton O, Smith A, Moon J, Demian M, Garfinkle R, Vasilevsky CA, Rajabiyazdi F, Boutros M.

Colorectal Disease. 2023 Sep;25(9):1812-1820.

Interactive online informational and peer support application for patients with low anterior resection syndrome: patient survey and protocol for a multicentre randomized controlled trial Moon J, Monton O, Smith A, Garfinkle R, Zhao K, Zelkowitz P, Loiselle C, Fiore JF Jr, Liberman S, Morin N, Faria J, Ghitulescu G, Vasilevsky CA, Bhatnagar S, Boutros M.

Colorectal Disease. 2021 May;23(5):1248-1257.

The impact of an interactive online informational and peer support application (app) for patients with low anterior resection syndrome (LARS) on quality of life: a multicenter randomized controlled trial. Moon J, Monton O, Smith A, Demian M, Sabboobeh S, Garfinkle R, Chamdroka M, Brown C, Chadi S, Kennedy E, Liberman S, Savard J, Vasilevsky CA, Fiore JF Jr, Loiselle C, Zelkowitz P, Bhatnagar S, Boutros M.

Surgical Endoscopy. 2025 Feb;39(2):1308-1317.

The role of colonic motility in low anterior resection syndrome. Varghese C, Wells CI, Bissett IP, O’Grady G, Keane C.

Frontiers in Oncology. 2022 Sep 16;12:975386.

Functional Outcome of Laparoscopic-Assisted Resection Versus Open Resection of Rectal Cancer: A Secondary Analysis of the Australasian Laparoscopic Cancer of the Rectum Trial Keane CR, O’Grady G, Bissett IP, Hayes JL, Hulme-Moir M, Eglinton TW, Solomon MJ, Lumley JW, Simes J, Stevenson AR.

Diseases of the Colon & Rectum. 2022 Jul 1;65(7):e698-706.

The longitudinal course of low-anterior resection syndrome: an individual patient meta-analysis. Varghese C, Wells CI, O’Grady G, Christensen P, Bissett IP, Keane C.

Annals of Surgery. 2022 Jul 1;276(1):46-54.

Altered colonic motility is associated with low anterior resection syndrome Keane C, Paskaranandavadivel N, Vather R, Rowbotham D, Arkwright J, Dinning P, Bissett I, O’Grady G.

Colorectal Disease. 2021 Feb;23(2):415-23. DOI: 10.1111/codi.15465

Comparison of bowel dysfunction between colorectal cancer survivors and a non-operative non-cancer control group Keane C, O’Grady G, Bissett I, Woodfield J.

Colorectal Disease. 2020 Jul;22(7):806-13. DOI: 10.1111/codi.14966

Impact of temporary ileostomy on long-term quality of life and bowel function: a systematic review and meta-analysis Keane C, Sharma P, Yuan L, Bissett I, O'Grady G.

ANZ Journal of Surgery. 2020 May;90(5):687-92. DOI: 10.1111/ans.15552

International Consensus Definition of Low Anterior Resection Syndrome Keane C, Fearnhead NS, Bordeianou LG, Christensen P, Basany EE, Laurberg S, Mellgren A, Messick C, Orangio GR, Verjee A, Wing K, Bissett I.

Diseases of the Colon & Rectum. 2020 Mar 1;63(3):274-84. DOI: 10.1097/DCR.0000000000001583

Functional outcomes from a randomized trial of early closure of temporary ileostomy after rectal excision for cancer Keane C, Park J, Öberg S, Wedin A, Bock D, O'Grady G, Bissett I, Rosenberg J, Angenete E.

Journal of British Surgery. 2019 Apr;106(5):645-52. DOI: 10.1002/bjs.11092

Defining low anterior resection syndrome: a systematic review of the literature Keane C, Wells C, O'grady G, Bissett IP.

Colorectal Disease. 2017 Aug;19(8):713-22. DOI: 10.1111/codi.13767

Percutaneous tibial nerve stimulation in patients with severe low anterior resection syndrome: randomized clinical trial Marinello F, Jime ́nez LM, Talavera E, Fraccalvieri D, Alberti P, Ostiz F, Frago R, Blanco A, Pellino G, Espín-Basany E.

British Journal of Surgery. 2021 Apr; 108(4): 380–387. DOI: 10.1093/bjs/znaa171

Low anterior resection syndrome: An unavoidable price to pay to preserve the rectum? Marinello F, Pellino G, Espín-Basany E.

Frontiers in Oncology. 2022 Oct 14;12:994720. DOI: 10.3389/fonc.2022.994720

Sacral Neuromodulation in Patients With Low Anterior Resection Syndrome: The SANLARS Randomized Clinical Trial Marinello F, Fraccalvieri D, Planellas P, Adell Trapé M, Gil JM, Kreisler E, Pellino G, Espín-Basany E.

Diseases of the Colon & Rectum. 2024 Mar 1;67(3):435-447. DOI: 10.1097/DCR.0000000000003143

Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort, with economic evaluation, process evaluation and qualitative sub-study, to explore the natural history of LARS and compare transanal irrigation and sacral neuromodulation to optimised conservative management for people with major LARS following a high or low anterior resection for colorectal cancer Croft J, Farrow E, Coxon-Meggy AH, Gordon K, Corrigan N, Mather H, Stocken DD, Dale M, Chong HY, White J, Knight L, Meggy A, Lloydwin C, Tan B, Douglas A, Powell R, Hepburn J, Jayne D, Torkington J, Warwick A, Ng KS, Wilson K, Knowles CH, Quyn A, Cornish J.

BMJ Open. 2025 Feb 3;15(2):e092612. DOI: 10.1136/bmjopen-2024-092612

Low anterior resection syndrome phenotypes—Different symptom profiles for different patients Koneru S, Cornish J, Chapuis PH, Keshava A, Rickard MJFX, Ng KS.

Colorectal Disease. 2024 Jun;26(6):1214-1222. DOI: 10.1111/codi.17034

Major low anterior resection syndrome has equivalent health-related quality of life implications as having a permanent colostomy. Koneru S, Builth-Snoad L, Rickard MJFX, Keshava A, Chapuis PH, Ng KS.

Techniques in Coloproctology. 2023 Dec 15;28(1):17. DOI: 10.1007/s10151-023-02879-y

LARS: A review of therapeutic options and their efficacy Ng KS, Gladman MA.

Seminars in Colon and Rectal Surgery. 2021; 32(4).

Patient-reported and physician-recorded bowel dysfunction following colorectal resection and radical cystectomy: a prospective, comparative study Ng KS, Gladman MA.

Colorectal Disease. 2020;22(10):1336-1347. DOI: 10.1111/codi.15041

Colonic transit in patients after anterior resection: prospective, comparative study using single-photon emission CT/CT scintigraphy Ng KS, Russo R, Gladman MA.

British Journal of Surgery. 2020;107(5):567-79. DOI: 10.1002/bjs.11471

Diagnostic accuracy of intraoperative pelvic autonomic nerve monitoring during rectal surgery: a systematic review. O'Connor A, Rengifo C, Griffiths B, Cornish JA, Tiernan JP, Khan J, Nunoo-Mensah JW, Telford K, Harji D.

Techniques in Coloproctology. 2024 Dec 6;29(1):8. DOI: 10.1007/s10151-024-03043-w

Pathway Of Low Anterior Resection syndrome relief after Surgery (POLARiS) feasibility trial protocol: a multicentre, feasibility cohort study with embedded randomised control trial to compare sacral neuromodulation and transanal irrigation to optimised conservative management in the management of major low anterior resection syndrome following rectal cancer treatment. Coxon-Meggy AH, Vogel I, White J, Croft J, Corrigan N, Meggy A, Stocken DD, Keller D, Hompes R, Knowles CH, Quyn A, Cornish J.

BMJ Open. 2023;13(1):e064248. DOI: 10.1136/bmjopen-2022-064248

Physiotherapy and Anterior Resection Syndrome (Paris) Trial A Feasibility Study to Assessing if a Preoperative Education and Physiotherapy Session Before an Anterior Resection, and a 3 Month Pelvic Floor Muscle Rehabilitation Programme Prior to Ileostomy Reversal are Feasible. Vogel I, de Berker H, McCabe G, Powell-Chandler A, Rees B, Torkington J, O’Neill C, Cornish J.

Journal of Surgery (2022) 7: 1574. DOI: https://doi.org/10.29011/2575-9760.001574

Impact of a defunctioning ileostomy and time to stoma closure on bowel function after low anterior resection for rectal cancer: a systematic review and meta-analysis. Vogel I, Reeves N, Tanis PJ, Bemelman WA, Torkington J, Hompes R, Cornish JA.

Techniques in Coloproctology. 2021 Jul;25(7):751-760. DOI: 10.1007/s10151-021-02436-5

Factors impacting time to ileostomy closure after anterior resection: the UK closure of ileostomy timing cohort study (CLOSE‐IT) Dukes’ Club Research Collaborative (steering group)

Colorectal Disease 16 January 2021 https://doi.org/10.1111/codi.15531

Psychological sequelae of colonic resections. Powell-Chandler A, Boyce K, James O, Scourfield L, Torkington J, Bisson J, Cornish JA.

Colorectal Disease. 2020 Aug;22(8):945-951. https://doi.org/10.1111/codi.14986

Protocol for a multicentre, dual prospective and retrospective cohort study investigating timing of ileostomy closure after anterior resection for rectal cancer: The CLOSurE of Ileostomy Timing (CLOSE-IT) study Vaughan-Shaw PG, Gash K, Adams K, Vallance A, Pilkington SA, Torkington J, Cornish JA.

BMJ Open. 2018 Oct15;8(10):e023305 http://doi.org/10.1136/bmjopen-2018-023305

Physiotherapy and Anterior Resection Syndrome (PARiS) trial: feasibility study protocol. Powell-Chandler A, Rees B, Broad C, Torkington J, O’Neill C, Cornish JA.

BMJ Open 2018; 8(6), e021855. https://doi.org/10.1136/bmjopen-2018-021855

Acceptability and benefit of rectal irrigation in patients with Low Anterior Resection Syndrome: a qualitative study. McCutchan GM, Hughes D, Davies Z, Torkington J, Morris C, Cornish JA.

. Colorectal Disease. Dec 2017: 76-84. https://doi.org/10.1111/codi.13985

Functional outcome following rectal surgery—predisposing factors for low anterior resection syndrome Hughes DL, Cornish J, Morris C.

International Journal of Colorectal Disease, 32(5), 691–697 (2017). https://doi.org/10.1007/s00384-017-2765-0

Low Anterior Resection Syndrome in a Reference North American Sample: Prevalence and Associated Factors. Moon J, Ehlebracht A, Cwintal M, Faria J, Ghitulescu G, Morin N, Pang A, Vasilevsky CA, Boutros M.

. Journal American College of Surgeons. 2023 Nov1;237(5):679-688. DOI: 10.1097/XCS.0000000000000807

Low Anterior Resection Syndrome: Predisposing Factors and Treatment. Garfinkle R, Boutros M.

Surgical Oncology. 2022 Aug;43:101691. DOI: 10.1016/j.suronc.2021.101691

Financial and Occupational Impact of Low Anterior Resection Syndrome in Rectal Cancer Survivors. Garfinkle R, Ky Aurelie, Aashiyan S, Morin N, Ghitulescu G, Faria J, Vasilevsky CA, Boutros M.

Colorectal Disease. 2021 Jul;23(7):1777-1784. DOI: 10.1111/codi.15633

Development and evaluation of a patient-centered program for low anterior resection syndrome: protocol for a randomized controlled trial. Garfinkle R, Loiselle CG, Park J, Fiore JF Jr, Bordeianou LG, Liberman SA, Morin N, Faria J, Ghitulescu G, Vasilevsky CA, Bhatnagar SR, Boutros M.

BMJ Open. 2020 May 30;10(5):e035587. DOI: 10.1136/bmjopen-2019-035587

Assessing the readability, quality and accuracy of online health information for patients with low anterior resection syndrome following surgery for rectal cancer Garfinkle R, Wong-Chong N, Petrucci A, Sylla P, Wexner SD, Bhatnagar S, Morin N, Boutros M.

Colorectal Disease. 2019 May;21(5):523-531. DOI: 10.1111/codi.14548.

Assessment of long-term bowel dysfunction after restorative proctectomy for neoplastic disease: A population-based cohort study. Garfinkle R, Dell’Aniello S, Bhatnagar S, Morin N, Ghitulescu G, Faria J, Vasilevsky CA, Brassard P, Boutros M.

Surgery. 2022 Sep;172(3)782-788. DOI: 10.1016/j.surg.2021.10.068

Systematic review and meta-analysis of randomized clinical trials on the treatment of low anterior resection syndrome. Emile SH, Garoufalia Z, Barsom S, Horesh N, Gefen R, Zhou P, Wexner SD.

Surgery. 2023 Jun;173(6):1352-1358. DOI: 10.1016/j.surg.2023.02.010

Low Anterior Resection Syndrome Score: Development and Validation of a Symptom-Based Scoring System for Bowel Dysfunction After Low Anterior Resection for Rectal Cancer. Emmertsen K, Laurberg S.

Annals of Surgery 255(5):p 922-928, May 2012. DOI: 10.1097/SLA.0b013e31824f1c21

Predicting the Risk of Bowel-Related Quality-of-Life Impairment After Restorative Resection for Rectal Cancer: A Multicenter Cross-Sectional Study. Battersby, NJ, Juul T, Christensen P, Janjua A, Branagan G, Emmertsen K, Norton C, Hughes R, Laurberg S, Moran BJ on behalf of the United Kingdom Low Anterior Resection Syndrome Study Group.

Diseases of the Colon & Rectum 59(4):p 270-280, April 2016. DOI: 10.1097/DCR.0000000000000552

Management guidelines for low anterior resection syndrome – the Manuel project. Christensen P, Im Baeten C, Espín-Basany E, Martellucci J, Nugent KP, Zerbib F, Pellino G, Rosen H, MANUEL Project Working Group.

Colorectal Disease. 2021 Feb;23(2):461-475. DOI: 10.1111/codi.15517

A Randomized Controlled Clinical Trial of Transanal Irrigation Versus Conservative Treatment in Patients with Low Anterior Resection Syndrome After Rectal Cancer Surgery. *Pieniowski EHA, Bergström CM, Nordenvall CAM, Westberg KS, Johar AM, Tumlin Ekelund SF, Larsson KR, Pekkari KJ, Jansson Palmer GC, Lagergren P, Abraham-Nordling M.

Annals of Surgery. 2023 Jan 1;277(1):30-37. DOI: 10.1097/SLA.0000000000005482

Low Anterior Resection Syndrome and Quality of Life: An International Multicenter Study. Juul T, Ahlberg M, Biondo S, Espin E, Jimenez LM, Matzel K, Palmer GJ, Sauermann A, Trenti L, Zhang W, Laurberg S, Christensen P.

Diseases of the Colon & Rectum 57(5):p 585-591, May 2014. DOI: 10.1097/DCR.0000000000000116

Altered anal slow-wave pressure activity in low anterior resection syndrome: short case series in two independent specialist centres provide new mechanistic insights. Vollebregt PF, Wiklendt L, Ang D, Venn ML, Mekhael M, Christensen P, Dinning PG, Knowles CH, Scott SM.

Colorectal Dis. 2021 Feb;23(2):444-450. doi: 10.1111/codi.15502. Epub 2021 Jan 3.PMID: 33342038

Development and external validation of a nomogram and online tool to predict bowel dysfunction following restorative rectal cancer resection: the POLARS score Battersby NJ, Bouliotis G, Emmertsen KJ, Juul T, Glynne-Jones R, Branagan G, Christensen P, Laurberg S, Moran BJ; UK and Danish LARS Study Groups.

Gut. 2018 Apr;67(4):688-696. doi: 10.1136/gutjnl-2016-312695. Epub 2017 Jan 23. PMID: 28115491

Long-term anorectal function in rectal cancer patients treated with chemoradiotherapy and endorectal brachytherapy. Faaborg PM, Haas S, Liao D, Ploen J, Jakobsen A, Rahr HB, Laurberg S, Gregersen H, Lundby L, Christensen P, Krogh K.

Colorectal Dis. 2021 Sep;23(9):2311-2319. doi: 10.1111/codi.15692. Epub 2021 Jun 14. PMID: 33900676

Anal sphincter dysfunction in patients treated with primary radiotherapy for anal cancer: a study with the functional lumen imaging probe. Haas S, Faaborg P, Liao D, Laurberg S, Gregersen H, Lundby L, Christensen P, Krogh K.

Acta Oncol. 2018 Apr;57(4):465-472. doi: 10.1080/0284186X.2018.1438658. Epub 2018 Feb 15.PMID: 29447025

Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer. Emmertsen KJ, Laurberg S.

Ann Surg. 2012 May;255(5):922-8. doi: 10.1097/SLA.0b013e31824f1c21. PMID: 22504191

The Longitudinal Course of Low-anterior Resection Syndrome: An individual Patient Meta-analysis. Varghese C, Wells CI, O'Grady G, Christensen P, Bissett IP, Keane C; on behalf of the Longitudinal LARS Group.

Ann Surg. 2022 Jul 1;276(1):46-54. doi: 10.1097/SLA.0000000000005423. Epub 2022 Feb 17. PMID: 35185131

International consensus definition of low anterior resection syndrome. Keane C, Fearnhead NS, Bordeianou LG, Christensen P, Espin Basany E, Laurberg S, Mellgren A, Messick C, Orangio GR, Verjee A, Wing K, Bissett IP; LARS International Collaborative Group.

ANZ J Surg. 2020 Mar;90(3):300-307. doi: 10.1111/ans.15421. Epub 2020 Feb 10. PMID: 32040983

Nurse-led standardized intervention for low anterior resection syndrome. A population-based pilot study. Dalsgaard P, Emmertsen KJ, Mekhael M, Laurberg S, Christensen P.

Colorectal Dis. 2021 Feb;23(2):434-443. doi: 10.1111/codi.15497. Epub 2021 Feb 9. PMID: 33340218

Normative Data for the Low Anterior Resection Syndrome Score (LARS Score). Juul T, Elfeki H, Christensen P, Laurberg S, Emmertsen KJ, Bager P.

Ann Surg. 2019 Jun;269(6):1124-1128. doi: 10.1097/SLA.0000000000002750. PMID: 31082911

Altered colonic motility is associated with low anterior resection syndrome. Keane C, Paskaranandavadivel N, Vather R, Rowbotham D, Arkwright J, Dinning P, Bissett I, O'Grady G.

Colorectal Dis. 2021 Feb;23(2):415-423. doi: 10.1111/codi.15465. Epub 2020 Dec 14. PMID: 33253472

International validation of the low anterior resection syndrome score. Juul T, Ahlberg M, Biondo S, Emmertsen KJ, Espin E, Jimenez LM, Matzel KE, Palmer G, Sauermann A, Trenti L, Zhang W, Laurberg S, Christensen P.

Ann Surg. 2014 Apr;259(4):728-34. doi: 10.1097/SLA.0b013e31828fac0b. PMID: 23598379

Treatment of Low Anterior Resection Syndrome in Specialized Multidisciplinary Late Sequelae Clinics: A Prospective Cohort Study. Mekhael M, Kristensen HØ, Borre M, Drewes AM, Emmertsen KJ, Fassov J, Krogh K, Lauritzen MB, Laurberg S, Poulsen JL, Thorlacius-Ussing O, Christensen P, Juul T.

Ann Surg. 2025 Apr 2. doi: 10.1097/SLA.0000000000006714. Online ahead of print. PMID: 40168548

Altered anal slow-wave pressure activity in low anterior resection syndrome: short case series in two independent specialist centres provide new mechanistic insights. Vollebregt PF, Wiklendt L, Ang D, Venn ML, Mekhael M, Christensen P, Dinning PG, Knowles CH, Scott SM.

Colorectal Dis. 2021 Feb;23(2):444-450. doi: 10.1111/codi.15502. Epub 2021 Jan 3. PMID: 33342038

Development and external validation of a nomogram and online tool to predict bowel dysfunction following restorative rectal cancer resection: the POLARS score. Battersby NJ, Bouliotis G, Emmertsen KJ, Juul T, Glynne-Jones R, Branagan G, Christensen P, Laurberg S, Moran BJ; UK and Danish LARS Study Groups.

Gut. 2018 Apr;67(4):688-696. doi: 10.1136/gutjnl-2016-312695. Epub 2017 Jan 23. PMID: 28115491

Interactive online informational and peer support application for patients with low anterior resection syndrome: patient survey and protocol for a multicentre randomized controlled trial. Moon J, Monton O, Smith A, Garfinkle R, Zhao K, Zelkowitz P, Loiselle CG, Fiore JF Jr, Sender Liberman A, Morin N, Faria J, Ghitulescu G, Vasilevsky CA, Bhatnagar SR, Boutros M.

Colorectal Dis. 2021 May;23(5):1248-1257. doi: 10.1111/codi.15602. Epub 2021 Apr 2. PMID: 33638278

Patient perspective on adapting to bowel dysfunction after rectal cancer surgery. Maalouf MF, Wang A, Robitaille S, Liberman AS, Fiore JF Jr, Feldman LS, Lee L.

Colorectal Dis. 2024 Sep;26(9):1701-1710. doi: 10.1111/codi.17118. Epub 2024 Aug 4. PMID: 39099084

Anal sphincter dysfunction in patients treated with primary radiotherapy for anal cancer: a study with the functional lumen imaging probe. Haas S, Faaborg P, Liao D, Laurberg S, Gregersen H, Lundby L, Christensen P, Krogh K.

Acta Oncol. 2018 Apr;57(4):465-472. doi: 10.1080/0284186X.2018.1438658. Epub 2018 Feb 15. PMID: 29447025

Functional Outcome of Laparoscopic-Assisted Resection Versus Open Resection of Rectal Cancer: A Secondary Analysis of the Australasian Laparoscopic Cancer of the Rectum Trial. Keane CR, O'Grady G, Bissett IP, Hayes JL, Hulme-Moir M, Eglinton TW, Solomon MJ, Lumley JW, Simes J, Stevenson ARL.

Dis Colon Rectum. 2022 Jul 1;65(7):e698-e706. doi:10.1097/DCR.0000000000002166. Epub 2022 Nov 11.

The impact of an interactive online informational and peer support application (app) for patients with low anterior resection syndrome (LARS) on quality of life: a multicenter randomized controlled trial. Moon J, Monton O, Smith A, Demian M, Sabboobeh S, Garfinkle R, Chamdroka M, Brown C, Chadi S, Kennedy E, Liberman S, Savard J, Vasilevsky CA, Fiore JF Jr, Loiselle C, Zelkowitz P, Bhatnagar S, Boutros M.

Surg Endosc. 2025 Feb;39(2):1308-1317. doi: 10.1007/s00464-024-11425-2. Epub 2025 Jan 8. PMID: 39779532 Clinical Trial.

Long-term anorectal function in rectal cancer patients treated with chemoradiotherapy and endorectal brachytherapy. Faaborg PM, Haas S, Liao D, Ploen J, Jakobsen A, Rahr HB, Laurberg S, Gregersen H, Lundby L, Christensen P, Krogh K.

Colorectal Dis. 2021 Sep;23(9):2311-2319. doi: 10.1111/codi.15692. Epub 2021 Jun 14. PMID: 33900676

International Consensus Definition of Low Anterior Resection Syndrome. Keane C, Fearnhead NS, Bordeianou LG, Christensen P, Basany EE, Laurberg S, Mellgren A, Messick C, Orangio GR, Verjee A, Wing K, Bissett I; LARS International Collaborative Group.

Dis Colon Rectum. 2020 Mar;63(3):274-284. doi: 10.1097/DCR.0000000000001583. PMID: 32032141

Management guidelines for low anterior resection syndrome - the MANUEL project. Christensen P, Im Baeten C, Espín-Basany E, Martellucci J, Nugent KP, Zerbib F, Pellino G, Rosen H; MANUEL Project Working Group.

Colorectal Dis. 2021 Feb;23(2):461-475. doi: 10.1111/codi.15517. Epub 2021 Jan 24. PMID: 33411977

What Are the Best Questionnaires To Capture Anorectal Function After Surgery in Rectal Cancer? Chen TY, Emmertsen KJ, Laurberg S.

Curr Colorectal Cancer Rep. 2015;11(1):37-43. doi: 10.1007/s11888-014-0217-6. PMID: 25663833

The role of colonic motility in low anterior resection syndrome. Varghese C, Wells CI, Bissett IP, O'Grady G, Keane C.

Front Oncol. 2022 Sep 16;12:975386. doi: 10.3389/fonc.2022.975386. eCollection 2022. PMID: 36185226

Validation of low anterior resection syndrome score in Brazil with Portuguese. Buzatti KCLR, Petroianu A, Laurberg S, Silva RG, Rodrigues BDS, Christensen P, Lacerda-Filho A, Juul T.

Ann Coloproctol. 2023 Oct;39(5):402-409. doi: 10.3393/ac.2022.00136.0019. Epub 2022 May 13. PMID: 35569837

Does the Low Anterior Resection Syndrome Score Accurately Represent the Impact of Bowel Dysfunction on Health-Related Quality of Life? Wang A, Robitaille S, Liberman S, Feldman LS, Fiore JF Jr, Lee L.

J Gastrointest Surg. 2023 Jan;27(1):114-121. doi: 10.1007/s11605-022-05481-z. Epub 2022 Oct 17. PMID: 36253504

Transanal Irrigation for Neurogenic Bowel Disease, Low Anterior Resection Syndrome, Faecal Incontinence and Chronic Constipation: A Systematic Review. Mekhael M, Kristensen HØ, Larsen HM, Juul T, Emmanuel A, Krogh K, Christensen P. J Clin

Med. 2021 Feb 13;10(4):753. doi: 10.3390/jcm10040753. PMID: 33668658

Pathway Of Low Anterior Resection syndrome relief after Surgery (POLARiS) feasibility trial protocol: a multicentre, feasibility cohort study with embedded randomised control trial to compare sacral neuromodulation and transanal irrigation to optimised conservative management in the management of major low anterior resection syndrome following rectal cancer treatment. Coxon-Meggy AH, Vogel I, White J, Croft J, Corrigan N, Meggy A, Stocken DD, Keller D, Hompes R, Knowles CH, Quyn A, Cornish J.

BMJ Open. 2023 Jan 10;13(1):e064248. doi: 10.1136/bmjopen-2022-064248. PMID: 36627161

Coping strategies and considerations regarding low anterior resection syndrome and quality of life among patients with rectal cancer; a qualitative interview study. Laursen BS, Sørensen GK, Majgaard M, Jensen LB, Jacobsen KI, Kjær DK, Juul T, Christensen P, Mikkelsen AH.

Front Oncol. 2022 Nov 29;12:1040462. doi: 10.3389/fonc.2022.1040462. eCollection 2022. PMID: 36523984

Effect of melatonin in patients with low anterior resection syndrome (MELLARS): a study protocol for a randomised, placebo-controlled, crossover trial. Zahid JA, Madsen MT, Bulut O, Christensen P, Gögenur I.

BMJ Open. 2023 Sep 11;13(9):e067763. doi: 10.1136/bmjopen-2022-067763. PMID: 37696629

Development and evaluation of a patient-centred program for low anterior resection syndrome: protocol for a randomized controlled trial. Garfinkle R, Loiselle CG, Park J, Fiore JF Jr, Bordeianou LG, Liberman AS, Morin N, Faria J, Ghitulescu G, Vasilevsky CA, Bhatnagar SR, Boutros M.

BMJ Open. 2020 May 30;10(5):e035587. doi: 10.1136/bmjopen-2019-035587. PMID: 32474427

The use of patient-generated health data in the management of low anterior resection syndrome: a qualitative study. Monton O, Smith A, Sabboobeh S, Demian M, Cornish J, Wexner SD, Christensen P, Ghuman A, Bordeianou LG, Keane C, Husain S, Gasior A, Leon N, Savard J, Savitt LR, Majgaard M, Sørensen GK, Mills M, Rajabiyazdi F, Boutros M.

Front Surg. 2024 Dec 19;11:1506688. doi: 10.3389/fsurg.2024.1506688. eCollection 2024. PMID: 39749126

Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort, with economic evaluation, process evaluation and qualitative sub-study, to explore the natural history of LARS and compare transanal irrigation and sacral neuromodulation to optimised conservative management for people with major LARS following a high or low anterior resection for colorectal cancer Croft J, Farrow E, Coxon-Meggy AH, Gordon K, Corrigan N, Mather H, Stocken DD, Dale M, Chong HY, White J, Knight L, Meggy A, Lloydwin C, Tan B, Douglas A, Powell R, Hepburn J, Jayne D, Torkington J, Warwick A, Ng KS, Wilson K, Knowles CH, Quyn A, Cornish J.

BMJ Open. 2025 Feb 3;15(2):e092612. doi: 10.1136/bmjopen-2024-092612. PMID: 39900423

Comparative analysis of the Memorial Sloan Kettering Bowel Function Instrument and the Low Anterior Resection Syndrome Questionnaire for assessment of bowel dysfunction in rectal cancer patients after low anterior resection. Quezada-Diaz FF, Elfeki H, Emmertsen KJ, Pappou EP, Jimenez-Rodriguez R, Patil S, Laurberg S, Garcia-Aguilar J.

Colorectal Dis. 2021 Feb;23(2):451-460. doi: 10.1111/codi.15515. Epub 2021 Feb 10. PMID: 33405307

Is transanal irrigation the best treatment possibility for low anterior resection syndrome? A multicenter, randomized clinical trial: study protocol. Klimovskij M, Civilka I, Aleinikov A, Aukstikalnis T, Christensen P, Dulskas A.

Front Surg. 2024 May 13;11:1384815. doi: 10.3389/fsurg.2024.1384815. eCollection 2024. PMID: 38803549

Bowel dysfunction after rectal cancer treatment: a study comparing the specialist's versus patient's perspective. Chen TY, Emmertsen KJ, Laurberg S.

BMJ Open. 2014 Jan 21;4(1):e003374. doi: 10.1136/bmjopen-2013-003374. PMID: 24448844

Prevalence of self-reported abdominal symptoms among 50-74-years-old men and women eligible for colorectal cancer screening -a cross-sectional study. Larsen MB, Bachmann HH, Søborg B, Laurberg T, Emmertsen KJ, Laurberg S, Andersen B.

BMC Cancer. 2021 Aug 10;21(1):910. doi: 10.1186/s12885-021-08657-z. PMID: 34376179

Treatment of Low Anterior Resection Syndrome in Specialized Multidisciplinary Late Sequelae Clinics A Prospective Cohort Study Mekhael, Mira MD, PhD, Kristensen, Helle MD, PhD, Borre, Mette RD, Drewes, Asbjørn M. MD, PhD, DMSc, Emmertsen, Katrine J. MD, PhD, Fassov, Janne MD, PhD, Krogh, Klaus MD, PhD, DMSc, Lauritzen, Michael B. MD, Laurberg, Søren MD, DMSc, Poulsen, Jakob Lykke MD, PhD, Thorlacius-Ussing, Ole MD, PhD, DMSc, Christensen, Peter MD, PhD, DMSc, Juul, Therese MHSc, PhD

Annals of Surgery ():10.1097/SLA.0000000000006714, April 2, 2025. | DOI: 10.1097/SLA.0000000000006714

Publications

An online educational and supportive care application for rectal cancer survivors with low anterior resection syndrome: A mixed methods pilot study Monton O, Smith A, Moon J, Demian M, Garfinkle R, Vasilevsky CA, Rajabiyazdi F, Boutros M.

The role of colonic motility in low anterior resection syndrome. Varghese C, Wells CI, Bissett IP, O’Grady G, Keane C.

Functional Outcome of Laparoscopic-Assisted Resection Versus Open Resection of Rectal Cancer: A Secondary Analysis of the Australasian Laparoscopic Cancer of the Rectum Trial Keane CR, O’Grady G, Bissett IP, Hayes JL, Hulme-Moir M, Eglinton TW, Solomon MJ, Lumley JW, Simes J, Stevenson AR.

The longitudinal course of low-anterior resection syndrome: an individual patient meta-analysis. Varghese C, Wells CI, O’Grady G, Christensen P, Bissett IP, Keane C.

Altered colonic motility is associated with low anterior resection syndrome Keane C, Paskaranandavadivel N, Vather R, Rowbotham D, Arkwright J, Dinning P, Bissett I, O’Grady G.

Comparison of bowel dysfunction between colorectal cancer survivors and a non-operative non-cancer control group Keane C, O’Grady G, Bissett I, Woodfield J.

Impact of temporary ileostomy on long-term quality of life and bowel function: a systematic review and meta-analysis Keane C, Sharma P, Yuan L, Bissett I, O'Grady G.

International Consensus Definition of Low Anterior Resection Syndrome Keane C, Fearnhead NS, Bordeianou LG, Christensen P, Basany EE, Laurberg S, Mellgren A, Messick C, Orangio GR, Verjee A, Wing K, Bissett I.

Functional outcomes from a randomized trial of early closure of temporary ileostomy after rectal excision for cancer Keane C, Park J, Öberg S, Wedin A, Bock D, O'Grady G, Bissett I, Rosenberg J, Angenete E.

Defining low anterior resection syndrome: a systematic review of the literature Keane C, Wells C, O'grady G, Bissett IP.

Percutaneous tibial nerve stimulation in patients with severe low anterior resection syndrome: randomized clinical trial Marinello F, Jime ́nez LM, Talavera E, Fraccalvieri D, Alberti P, Ostiz F, Frago R, Blanco A, Pellino G, Espín-Basany E.

Low anterior resection syndrome: An unavoidable price to pay to preserve the rectum? Marinello F, Pellino G, Espín-Basany E.

Sacral Neuromodulation in Patients With Low Anterior Resection Syndrome: The SANLARS Randomized Clinical Trial Marinello F, Fraccalvieri D, Planellas P, Adell Trapé M, Gil JM, Kreisler E, Pellino G, Espín-Basany E.

Low anterior resection syndrome phenotypes—Different symptom profiles for different patients Koneru S, Cornish J, Chapuis PH, Keshava A, Rickard MJFX, Ng KS.

Major low anterior resection syndrome has equivalent health-related quality of life implications as having a permanent colostomy. Koneru S, Builth-Snoad L, Rickard MJFX, Keshava A, Chapuis PH, Ng KS.

LARS: A review of therapeutic options and their efficacy Ng KS, Gladman MA.

Patient-reported and physician-recorded bowel dysfunction following colorectal resection and radical cystectomy: a prospective, comparative study Ng KS, Gladman MA.

Colonic transit in patients after anterior resection: prospective, comparative study using single-photon emission CT/CT scintigraphy Ng KS, Russo R, Gladman MA.

Diagnostic accuracy of intraoperative pelvic autonomic nerve monitoring during rectal surgery: a systematic review. O'Connor A, Rengifo C, Griffiths B, Cornish JA, Tiernan JP, Khan J, Nunoo-Mensah JW, Telford K, Harji D.

Impact of a defunctioning ileostomy and time to stoma closure on bowel function after low anterior resection for rectal cancer: a systematic review and meta-analysis. Vogel I, Reeves N, Tanis PJ, Bemelman WA, Torkington J, Hompes R, Cornish JA.

Factors impacting time to ileostomy closure after anterior resection: the UK closure of ileostomy timing cohort study (CLOSE‐IT) Dukes’ Club Research Collaborative (steering group)

Psychological sequelae of colonic resections. Powell-Chandler A, Boyce K, James O, Scourfield L, Torkington J, Bisson J, Cornish JA.

Protocol for a multicentre, dual prospective and retrospective cohort study investigating timing of ileostomy closure after anterior resection for rectal cancer: The CLOSurE of Ileostomy Timing (CLOSE-IT) study Vaughan-Shaw PG, Gash K, Adams K, Vallance A, Pilkington SA, Torkington J, Cornish JA.

Physiotherapy and Anterior Resection Syndrome (PARiS) trial: feasibility study protocol. Powell-Chandler A, Rees B, Broad C, Torkington J, O’Neill C, Cornish JA.

Acceptability and benefit of rectal irrigation in patients with Low Anterior Resection Syndrome: a qualitative study. McCutchan GM, Hughes D, Davies Z, Torkington J, Morris C, Cornish JA.

Functional outcome following rectal surgery—predisposing factors for low anterior resection syndrome Hughes DL, Cornish J, Morris C.

Low Anterior Resection Syndrome in a Reference North American Sample: Prevalence and Associated Factors. Moon J, Ehlebracht A, Cwintal M, Faria J, Ghitulescu G, Morin N, Pang A, Vasilevsky CA, Boutros M.

Low Anterior Resection Syndrome: Predisposing Factors and Treatment. Garfinkle R, Boutros M.

Financial and Occupational Impact of Low Anterior Resection Syndrome in Rectal Cancer Survivors. Garfinkle R, Ky Aurelie, Aashiyan S, Morin N, Ghitulescu G, Faria J, Vasilevsky CA, Boutros M.

Development and evaluation of a patient-centered program for low anterior resection syndrome: protocol for a randomized controlled trial. Garfinkle R, Loiselle CG, Park J, Fiore JF Jr, Bordeianou LG, Liberman SA, Morin N, Faria J, Ghitulescu G, Vasilevsky CA, Bhatnagar SR, Boutros M.

Assessing the readability, quality and accuracy of online health information for patients with low anterior resection syndrome following surgery for rectal cancer Garfinkle R, Wong-Chong N, Petrucci A, Sylla P, Wexner SD, Bhatnagar S, Morin N, Boutros M.

Assessment of long-term bowel dysfunction after restorative proctectomy for neoplastic disease: A population-based cohort study. Garfinkle R, Dell’Aniello S, Bhatnagar S, Morin N, Ghitulescu G, Faria J, Vasilevsky CA, Brassard P, Boutros M.

Systematic review and meta-analysis of randomized clinical trials on the treatment of low anterior resection syndrome. Emile SH, Garoufalia Z, Barsom S, Horesh N, Gefen R, Zhou P, Wexner SD.

Low Anterior Resection Syndrome Score: Development and Validation of a Symptom-Based Scoring System for Bowel Dysfunction After Low Anterior Resection for Rectal Cancer. Emmertsen K, Laurberg S.

Management guidelines for low anterior resection syndrome – the Manuel project. Christensen P, Im Baeten C, Espín-Basany E, Martellucci J, Nugent KP, Zerbib F, Pellino G, Rosen H, MANUEL Project Working Group.

Low Anterior Resection Syndrome and Quality of Life: An International Multicenter Study. Juul T, Ahlberg M, Biondo S, Espin E, Jimenez LM, Matzel K, Palmer GJ, Sauermann A, Trenti L, Zhang W, Laurberg S, Christensen P.

Altered anal slow-wave pressure activity in low anterior resection syndrome: short case series in two independent specialist centres provide new mechanistic insights. Vollebregt PF, Wiklendt L, Ang D, Venn ML, Mekhael M, Christensen P, Dinning PG, Knowles CH, Scott SM.

Long-term anorectal function in rectal cancer patients treated with chemoradiotherapy and endorectal brachytherapy. Faaborg PM, Haas S, Liao D, Ploen J, Jakobsen A, Rahr HB, Laurberg S, Gregersen H, Lundby L, Christensen P, Krogh K.

Anal sphincter dysfunction in patients treated with primary radiotherapy for anal cancer: a study with the functional lumen imaging probe. Haas S, Faaborg P, Liao D, Laurberg S, Gregersen H, Lundby L, Christensen P, Krogh K.

Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer. Emmertsen KJ, Laurberg S.

The Longitudinal Course of Low-anterior Resection Syndrome: An individual Patient Meta-analysis. Varghese C, Wells CI, O'Grady G, Christensen P, Bissett IP, Keane C; on behalf of the Longitudinal LARS Group.

International consensus definition of low anterior resection syndrome. Keane C, Fearnhead NS, Bordeianou LG, Christensen P, Espin Basany E, Laurberg S, Mellgren A, Messick C, Orangio GR, Verjee A, Wing K, Bissett IP; LARS International Collaborative Group.

Nurse-led standardized intervention for low anterior resection syndrome. A population-based pilot study. Dalsgaard P, Emmertsen KJ, Mekhael M, Laurberg S, Christensen P.

Normative Data for the Low Anterior Resection Syndrome Score (LARS Score). Juul T, Elfeki H, Christensen P, Laurberg S, Emmertsen KJ, Bager P.

Altered colonic motility is associated with low anterior resection syndrome. Keane C, Paskaranandavadivel N, Vather R, Rowbotham D, Arkwright J, Dinning P, Bissett I, O'Grady G.

International validation of the low anterior resection syndrome score. Juul T, Ahlberg M, Biondo S, Emmertsen KJ, Espin E, Jimenez LM, Matzel KE, Palmer G, Sauermann A, Trenti L, Zhang W, Laurberg S, Christensen P.

Treatment of Low Anterior Resection Syndrome in Specialized Multidisciplinary Late Sequelae Clinics: A Prospective Cohort Study. Mekhael M, Kristensen HØ, Borre M, Drewes AM, Emmertsen KJ, Fassov J, Krogh K, Lauritzen MB, Laurberg S, Poulsen JL, Thorlacius-Ussing O, Christensen P, Juul T.

Altered anal slow-wave pressure activity in low anterior resection syndrome: short case series in two independent specialist centres provide new mechanistic insights. Vollebregt PF, Wiklendt L, Ang D, Venn ML, Mekhael M, Christensen P, Dinning PG, Knowles CH, Scott SM.

Patient perspective on adapting to bowel dysfunction after rectal cancer surgery. Maalouf MF, Wang A, Robitaille S, Liberman AS, Fiore JF Jr, Feldman LS, Lee L.

Anal sphincter dysfunction in patients treated with primary radiotherapy for anal cancer: a study with the functional lumen imaging probe. Haas S, Faaborg P, Liao D, Laurberg S, Gregersen H, Lundby L, Christensen P, Krogh K.

Functional Outcome of Laparoscopic-Assisted Resection Versus Open Resection of Rectal Cancer: A Secondary Analysis of the Australasian Laparoscopic Cancer of the Rectum Trial. Keane CR, O'Grady G, Bissett IP, Hayes JL, Hulme-Moir M, Eglinton TW, Solomon MJ, Lumley JW, Simes J, Stevenson ARL.

Long-term anorectal function in rectal cancer patients treated with chemoradiotherapy and endorectal brachytherapy. Faaborg PM, Haas S, Liao D, Ploen J, Jakobsen A, Rahr HB, Laurberg S, Gregersen H, Lundby L, Christensen P, Krogh K.

International Consensus Definition of Low Anterior Resection Syndrome. Keane C, Fearnhead NS, Bordeianou LG, Christensen P, Basany EE, Laurberg S, Mellgren A, Messick C, Orangio GR, Verjee A, Wing K, Bissett I; LARS International Collaborative Group.

Management guidelines for low anterior resection syndrome - the MANUEL project. Christensen P, Im Baeten C, Espín-Basany E, Martellucci J, Nugent KP, Zerbib F, Pellino G, Rosen H; MANUEL Project Working Group.

What Are the Best Questionnaires To Capture Anorectal Function After Surgery in Rectal Cancer? Chen TY, Emmertsen KJ, Laurberg S.

The role of colonic motility in low anterior resection syndrome. Varghese C, Wells CI, Bissett IP, O'Grady G, Keane C.

Validation of low anterior resection syndrome score in Brazil with Portuguese. Buzatti KCLR, Petroianu A, Laurberg S, Silva RG, Rodrigues BDS, Christensen P, Lacerda-Filho A, Juul T.

Does the Low Anterior Resection Syndrome Score Accurately Represent the Impact of Bowel Dysfunction on Health-Related Quality of Life? Wang A, Robitaille S, Liberman S, Feldman LS, Fiore JF Jr, Lee L.

Transanal Irrigation for Neurogenic Bowel Disease, Low Anterior Resection Syndrome, Faecal Incontinence and Chronic Constipation: A Systematic Review. Mekhael M, Kristensen HØ, Larsen HM, Juul T, Emmanuel A, Krogh K, Christensen P. J Clin

Coping strategies and considerations regarding low anterior resection syndrome and quality of life among patients with rectal cancer; a qualitative interview study. Laursen BS, Sørensen GK, Majgaard M, Jensen LB, Jacobsen KI, Kjær DK, Juul T, Christensen P, Mikkelsen AH.

Effect of melatonin in patients with low anterior resection syndrome (MELLARS): a study protocol for a randomised, placebo-controlled, crossover trial. Zahid JA, Madsen MT, Bulut O, Christensen P, Gögenur I.

Development and evaluation of a patient-centred program for low anterior resection syndrome: protocol for a randomized controlled trial. Garfinkle R, Loiselle CG, Park J, Fiore JF Jr, Bordeianou LG, Liberman AS, Morin N, Faria J, Ghitulescu G, Vasilevsky CA, Bhatnagar SR, Boutros M.

Is transanal irrigation the best treatment possibility for low anterior resection syndrome? A multicenter, randomized clinical trial: study protocol. Klimovskij M, Civilka I, Aleinikov A, Aukstikalnis T, Christensen P, Dulskas A.

Bowel dysfunction after rectal cancer treatment: a study comparing the specialist's versus patient's perspective. Chen TY, Emmertsen KJ, Laurberg S.

Prevalence of self-reported abdominal symptoms among 50-74-years-old men and women eligible for colorectal cancer screening -a cross-sectional study. Larsen MB, Bachmann HH, Søborg B, Laurberg T, Emmertsen KJ, Laurberg S, Andersen B.

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